Buried Alive follows the life of construction contractor Clint Goodman (Tim Matheson), a man who believes he has a happy marriage to the beautiful Joanna (Jennifer Jason Leigh). Unbeknownst to Clint, his wife has been having a serious affair with a physician named Dr. Cortland van Owen (William Atherton). The two secretly plan to murder Clint so that they can take his life insurance money and the proceeds from the sale of his business to move to Beverly Hills.
Cortland gives Joanna a lethal dose of tetrodotoxin, taken from a live puffer-fish in Buried Alive. She administers the poison in a glass of wine that she gives Clint with the promise that it will send her husband into cardiac arrest. Their plan seems to succeed at first, as Clint drops dead to the floor and is pronounced dead on arrival from a freak heart attack.
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